Facemask versus No Facemask in Preventing Viral Respiratory Infections During Hajj: A Cluster Randomised Open Label Trial

Архивировано 12.03.2021: alfelali-pre-2019.pdf

Источник: Alfelali M., et al. Facemask versus No Facemask in Preventing Viral Respiratory Infections During Hajj: A Cluster Randomised Open Label Trial SSRN, 2019-03-11, DOI:10.2139/ssrn.3349234

From October 13 to 17 in 2013, October 2 to 6 in 2014, and September 22 to 26 in 2015, 7,687 adult participants from 318 tents were randomised to facemasks or no facemasks; 3,864 participants from 149 tents were assigned to the Facemask group and 3,823 participants from 169 tents to the Control group. In the Facemask arm, respectively 27% and 51% participants used facemasks daily and intermittently, 22% did not; in the Control arm, respectively 15% and 38% participants used facemasks daily and intermittently, 47% did not. Respiratory viruses were detected in 277 of 650 (43%) nasal/pharyngeal swabs from symptomatic pilgrims. In intention-to-treat analysis, facemask use was neither effective against laboratory-confirmed vRTIs (OR 1.35, 95% CI 0.88-2.07) nor against CRI (OR 1.1, 95% CI 0.88-1.39), not even in per-protocol analysis (OR 1.2, 95% CI 0.87-1.69; OR 1.3, 95% CI 0.99-1.83).